A Drosophila I(kappa)B kinase complex required for Relish cleavage and antibacterial immunity
Article Abstract:
A Drosophila I(kappa)B kinase complex containing DmIKK(beta) and DMIKK(gamma) has been identified. The complex is necessary for Relish cleavage and antibacterial immunity. A yet-to-be-identified I(kappa)B kinase complex is apparently required for Rel protein activation via the Toll signaling pathway.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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The antibacterial arm of the Drosophila innate immune response requires an I(kappa)B kinase
Article Abstract:
The Drosophila innate immune response is discussed. It must have an I(kappa)B kinase for antibacterial activity. The ird5 gene has a sequence and phenotype that suggest ird5 to be specifically necessary for the activation of Relish, a Drosophila NF-(kappa)B family member.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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NF-kappaB signaling pathways in mammalian and insect innate immunity
Article Abstract:
NF-kappaB signaling pathways in mammalian and Drosophila innate immunity are discussed in this review article. Both similarities and differences are seen in comparisons. Similar pathogen-derived substances activate the innate immune response in both.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
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