A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans

Article Abstract:

Results reveal that acute intoxicating effects of ethanol are mediated by selective activation of BK potassium channels in Caenorhabditis elegans. Data suggest that slo-1 gene plays a main role in bringing about ethanol responses as indicated by the BK potassium channels encoded by sol-1. Furthermore, ethanol activation inhibits neuronal activity.

Industrial organic chemicals, not elsewhere classified, Ethanol, Ethyl Alcohol Manufacturing, Alcohol, Neurons, Drunkenness (Criminal law), Intoxication, Alcohol, Denatured

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Sumoylation silences the Plasma membrane leak K(super +) channel K2P1

Article Abstract:

The small ubiquitin-related modifier protein (SUMO) pathway is shown to operate at the plasma membrane to control ion channel function. Removal of the peptide adduct by SUMO protease reveals K2P1 to be a K(super +)-selective, pH-sensitive, openly rectifying channel regulated by reversible peptide linkage.

Science & research, Cell membranes, Messenger RNA, Ion channels, Ubiquitin-proteasome system

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Immunity to K1 killer toxin: internal TOK1 blockade

Article Abstract:

Research demonstrates that the K1 killer cells of Saccharomyces cerevisiae avoid cell death by in vivo produced K1 toxin by the inhibition of TOK1 potassium channels. Further, TOK1 blockade also prevents cell death by external toxin.

Statistical Data Included, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, Bacterial toxins, Saccharomyces

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