A genomic screen of autism: evidence for a multilocus etiology

Article Abstract:

A genomic screen of autism, the most severe of the pervasive developmental disorders, carried out using linkage analysis in 90 multiplex sibships with parents, for 98 independent affected sib pairs (ASPs), with follow-up in 49 other multiplex sibships with 50 ASPs is discussed, and evidence for a multilocus etiology is presented. Unaffected sibs were part of the analysis as well, and it was found that positional cloning of susceptibility loci by linkage analysis may be a very daunting task, so other approaches may be required.

United States, Australia, Statistical Data Included, Usage, Chromosome mapping, Genetic disorders

---

Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers

Article Abstract:

Linkage-disequilibrium analysis of autistic disorder has pointed to marker GABRB3 155CA-2 (MTDT 28.63, 10 df, P = .0014) in the 15q11-13 region as a positional and functional candidate. GABRB3 is a gamma-aminobutyric acid (subA) receptor subunit gene. The region 15q11-13 is also critical for Prader-Willi/Angelman syndrome. The study involved 138 families, primarily composed of one child with autistic disorder and parents.

GABA

---

Similar abstracts:

• Abstracts: The best of times, the worst of times. Optioning your drugs
• Abstracts: A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus
• Abstracts: Identification of Lactococcus lactis genes required for bacteriophage adsorption. Labeling of Bifidobacterium longum cells with [super 13]C-substituted leucine for quantitative proteomic analyses
• Abstracts: Specific detection of the gene for the extracellular neutral protease of Bacillus cereus by PCR and blot hybridization
• Abstracts: Analysis of 16S-23S rRNA intergenic spacer regions of Vibrio cholerae and Vibrio mimicus. Identification of essential operons with a Rhamnose-inducible promoter in Burkholderia cenocepacia

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.