Ventral neural patterning by Nkx homeoNkx6.1 controls somatic motor neuron and ventral interneuron fates
Article Abstract:
Ventral neural patterning by Nkx homeoNkx6.1 has been found to control somatic motor neuron and ventral interneuron fates. Patterns of neurogenesis in mice having a targeted mutation were studied. The mutants have a dorsal-to-ventral switch in identity of progenitors and fate of postmitotic neurons.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventrals spinal cord
Article Abstract:
A study was conducted to determine the physiological function of interneuron generation's sonic hedgehog (Shh)-independent, retinoid-activated pathway. Analyses of neurons, Evx1/2 (VO) and En1 (V1), and the ventral progenitors that express the Dbx homeodomain proteins show that Shh signalling in the ventral spinal cord increases the number of of Dbx cells and V0 and V1 formed. However, it is not essential to their initial generation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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