A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A (ital): a maximum-likelihood combined linkage and association analysis in twins and their sibs

Article Abstract:

A major quantitative-trait locus for mole density linked to the familial melanoma gene CDKN2A (ital) is discussed with information about a maximum-likelihood combined linkage and association analysis in twins and their siblings. Raised and flat nevi appear to have very differnt etiologies based on the findings of the study with total heritability higher for raised than for flat moles.

United States, Statistical Data Included, Usage, Genetic aspects, Chromosome mapping, Genetic disorders, Melanoma, Familial diseases

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Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples

Article Abstract:

A genomewide linkage screen of simple heavy-smoking quantitative trait is conducted using two independent samples. The study found significant evidence of linkage to chromosome 20 in the Finnish sample.

Finland, Science & research, Analysis, Causes of, Risk factors, Smoking, Lung cancer, Quantitative trait loci, Clinical report

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