Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination

Article Abstract:

Golgi cells expressing the human interleukin-2 receptor alpha subunit in transgenic mice underwent a novel cell ablation technology called immunotoxin-mediated cell targeting (IMCT) since the role played by Golgi cells in cerebellar function and motor coordination was unclear. The conditional disruption of the Golgi cells was through the administration of anti-TAC(Fv)-PE38 recombinant protein intrathecally. It was revealed that Golgi cell elimination resulted to severe motor disorders and weakening of the functional neurotransmitters needed in compound motor coordination.

Methods, Motor ability, Motor skills, Golgi apparatus, Genetically modified mice, Neurotransmitters, Ablation (Surgery)

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Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in gluRdelta2 mutant mice

Article Abstract:

The delta 2 subunit of the glutamate receptor (GLuR) channel is localized selectively in cerebellar Purkinje cells. Analysis by gene targeting has shown that it is important for motor coordination, as well as the formation of synapses between parallel fibers and Purkinje cells and between climbing fibers and Purkinje cells. Loss of the delta 2 subunit results in changes in the long-term depression of synaptic transmission between parallel fiber and Purkinje cells. Result suggests that synaptic plasticity is closely related to synapse formation in the cerebellum.

Research, Abnormalities, Synapses, Neurotransmitter receptors

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Impaired synapse elimination during cerebral development in PKC-gamma mutant mice

Article Abstract:

Protein kinase C-gamma (PKC-gamma) may function as a downstream element in eliminating excess climbing fiber (CF) synapses. Adult mutant mice lacking PKC-gamma show multiple CFs in 41% of the Purkinje cells (PCs) unlike the wild-type mice whose PCs have single CF innervation. The mutants have a normal anatomy and normal transmission of excitatory stimuli in CF-PC and the parallel fiber-PC synapses. The mutants show normal regression of multiple CF innervation until two weeks after birth followed by a reduction in regression.

Growth, Neurons, Protein kinases

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