An initial blueprint for myogenic differentiation
Article Abstract:
Genome-wide transcription factor binding and expression profiling were combined in order to assemble a regulatory network controlling the myogenic regulatory factors (MRFs)-MyoD and myogenin-and Myocyte Enhancer Factor 2 (MEF2). The studies highlight unanticipated biological insights related to muscle development and focus on new directions for studies on genes associated with muscle repair and response to stress and damage.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Switching of the core transcription machinery during myogenesis
Article Abstract:
The fate of the core promoter recognition complex, TFIID during skeletal myogenesis is assessed. The switching of core promoters are observed that provides organism a simple yet effective means of selectively turns on one transcriptional program while silencing many others.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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The Notch coactivator, MAML1 functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis
Article Abstract:
MAML1 (mastermind-like) acts as a coactivator for MEF2C (myocyte enhancer factor 2C) transcription and is essential for proper muscle development. Mechanistically, MAML1 appears to mediate cross-talk between Notch and MEF2 to influence myogenic differentiation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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- Abstracts: TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1. TOR, a central controller of cell growth
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