Analysis of randomly amplified polymorphic DNA (RAPD) for identifying genetic markers associated with canine hip dysplasia
Article Abstract:
A study was conducted to analyze randomly amplified polymorphic DNA in locating markers that cosegregate with increases in joint laxity in domestic dogs. The Boykin spaniel was utilized as a model to study canine hip dysplasia. Results indicated that canine hip dysplasia occurs in all dog breeds and supports differences in prevalence from 3% to 70% among breeds. Findings also showed that the founder effect is a critical factor influencing abnormally high incidences of different genetic diseases.
Publication Name: The Journal of Heredity
Subject: Biological sciences
ISSN: 0022-1503
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
An outcrossed canine pedigree for linkage analysis of hip dysplasia
Article Abstract:
A study was conducted to analyze an outcrossed canine pedigree for linkage analysis of canine hip dysplasia (CHD), a polygenic disease. Greyhounds and dysplastic Labrador retrievers were bred o determine the informative pedigree. Feeding schedules were designed to realize maximum growth rate for maximum expression of CHD. Results indicated that hip phenotype can be determined by hip joint laxity and chondro-osseous conformation.
Publication Name: The Journal of Heredity
Subject: Biological sciences
ISSN: 0022-1503
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Comparison of ribotyping and randomly amplified polymorphic DNA PCR for characterization of Vibrio vulnificus
- Abstracts: Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse
- Abstracts: PedCheck: a program for identification of genotype incompatibilities in linkage analysis
- Abstracts: A global haplotype analysis of the myotonic dystrophy locus: implications for the evolution of modern humans and for the origin of myotonic dystrophy mutations
- Abstracts: Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods