Assessment of linkage disequilibrium by the decay of haplotype sharing with application to fine-scale genetic mapping

Article Abstract:

Assessment of linkage disequilibrium carried out by the decay of haplotype sharing (DHS) and applied to fine-scale chromosome mapping is discussed. Cystic fibrosis and progressive myoclonus epilepsy are used as examples. Linkage disequilibrium (LD) is of much interest for mapping of genes and study of population history, so this multilocus model for LD is proposed. It is most useful when the LD of interest is the result of introduction of a variant on an ancestral haplotype with recombinations in later generations giving preservation of a small region of the ancestral haplotype around the variant. The approach works extremely well for fine mapping and for estimation of LD based on simulations.

Statistical Data Included, Methods, Models, Genetic aspects, Mathematical models, Simulation methods, Simulation, Mutation (Biology), Mutation, Population genetics, Cystic fibrosis, Markov processes, Medical statistics, Linkage (Genetics), Crossing over (Genetics), Biomathematics, Myoclonus

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Inbreeding effects on fertility in humans: evidence for reproductive compensation

Article Abstract:

Evidence of reproductive compensation has been found in inbred adults among Hutterites. Significantly reduced fecundity was found among the most inbred Hutterite women, who showed longer intervals between births and longer intervals between pregnancies. They did not show higher rates of fetal loss. It seems recessive alleles have an adverse effect on fecundity, but that completed family sizes are not different in the more-inbred women born after 1920 vs the less-inbred women. There is apparently compensation in the more-inbred less-fecund women.

Fertility, Human, Human fertility, Inbreeding

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