Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage
Article Abstract:
DNA damage-dependent links between phosphorylated Chk1 and 14-3-3 proteins suggest these mediate a significant step on the DNA-damage checkpoint path. The 14-3-3 proteins Rad24 and Rad25 interact with Chk1 in fission yeast. Once DNA is damaged, Chk1 is phosphorylated and the 14-3-3 proteins prefer binding to that form. In fission yeast, the interaction between 14-3-3 proteins and Cdc25 does not require Chk1 function.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
Article Abstract:
Research has been conducted on Hedgehog family of secreted proteins. The authors have discovered that transmembrane protein Smoothened transduces the Hedgehog signal via physical interaction with the Costal2/Fused protein complex.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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