Betaglycan presents ligand to the TGF-beta signaling receptor
Article Abstract:
Betaglycan (transforming growth factor-beta (TGF-beta) type III receptor), a distinct TGF-beta, binds membrane protein TGF beta to receptor II, develops a high affinity ternary complex, enhances cell sensitivity to TGF-beta and receptor binding affinity and removes significant differences between TGF-beta isoform. TGF-beta signals through a heteromeric protein receptor that possesses a resticted ability to bind ligand, and betaglycan overcomes this restriction. TGF-beta's access to the signaling receptors is directly controlled by betaglycan.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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MADR1, a MAD-related protein that functions in BMP2 signaling pathways
Article Abstract:
MAD (Mothers against dpp) belong to a novel class of signaling proteins that function downstream in the Ser/Thr kinase signaling pathways. MAD and its mammalian homolog MADR1 are regulated by signal transduction pathway of DPP/BMP2 (Decantaplegic/bone morphogenic protein2). The activation of BMP2 signaling pathways results in the quantitative phosphorylation of MADR1 in a specific tryptic peptide. MADR1 phosphorylation is not regulated by transforming growth factor beta and activin due to the specificity of MAD protein regulation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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