Calcium sensing and cell signaling processes in the local regulation of osteoclastic bone resorption

Article Abstract:

The cell physiological studies of the local mechanisms that regulate the resorptive process are reviewed. In addition, a speculation about the possible detailed models for these transduction events and their possible interactions with other systemic mechanisms involved in Ca(super 2+) homeostasis as well as the possible role of the RyR-based signaling mechanisms in longer-term cell regulatory processes are presented.

Bone resorption, Cellular control mechanisms, Cell regulation, Osteoclasis

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The brain's calendar: neural mechanisms of seasonal timing

Article Abstract:

A focus on the neuronal organization and dynamic properties of the biological clock, and the means by which it is synchronized with the environmental lighting conditions is brought out. It is shown that the functional activity of the biological clock is entrained to the seasonal photic cycle and that photoperiod may act as an effective zeitgeber.

Health aspects, Circadian rhythms, Melatonin, Photoperiodism, Pineal gland, Suprachiasmatic nucleus

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