Canine genetic linkage study using heterologous DNA probes

Article Abstract:

Segregation studies with heterologous single-copy human DNA probes in dogs indicate that different linkage groups present in humans are separate in dogs. The canine counterparts of the human serum amyloid gene group, however, have close linkages like the human genes. Hybridization signals are present in eight of the seventeen human clones when used with Southern blots of canine DNA. DNA markers attached to human genetic neuromuscular diseases are independent of hereditary canine spinal muscular atrophy.

Usage, DNA probes, Hybridization, Linkage (Genetics)

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Hereditary canine spinal muscular atrophy is phenotypically similar but molecularly distinct from human spinal muscular atrophy

Article Abstract:

A study was conducted to examine whether the canine survival motor neuron gene leads to hereditary canine spinal muscular atrophy (HCSMA) by analyzing a colony of mixed breed dogs. Results indicated that the gene did not support the mapping of the same chromosome as the HCSMA linkage group. Findings also showed that the molecular basis for HCSMA is different from human disorders caused by inherited mutations in the survival motor neuron gene.

Diseases, Motor neurons, Spinal muscular atrophy, Dog diseases

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Toward a framework linkage map of the canine genome

Article Abstract:

A study was conducted to map disease loci using a first-generation framework map of the canine genome. Large numbers of highly polymorphic markers and a panel of canine-rodent hybrid cell lines supported the model. The order and spacing of markers on single canine chromosomes were examined by linkage analysis. prcd was localized close to the centromeric end of canine chromosome 9 with various ordered markers in the region.

Genomes, Chromosome mapping

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