An NMR and enzyme study of the carbon metabolism of Neisseria meningitidis

Article Abstract:

The carbon metabolism of Neisseria meningitidis serogroup B strain (K454) has been studied using NMR and enzyme techniques. Expression of phosphotransacetylase (PTA) and acetate kinase (ACK) activities was not coordinately regulated during growth on combinations of carbon sources, which are perhaps related to the presence of two ackA paralogues unlinked to the pta gene in N. meningitidis.

Usage, Causes of, Environmental aspects, Metabolism, Cytochemistry, Protein kinases, Virulence (Microbiology), Nuclear magnetic resonance, Neisseria meningitidis, Meningitis, Cerebrospinal, Meningococcal meningitis

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The Burkholderia cepacia fur gene: co-localization with omlA and absence of regulation by iron

Article Abstract:

The Burkholderia cepacia fur gene is discussed relative to absence of regulation by iron and co-localization with omlA. The Fur (ferric uptake regulator) protein has a central role in control of iron-regulated genes so the fur gene of B. cepacia has been cloned and characterized as a move toward identification of genes of the organism's Fur regulon. The Burkholderia genus includes various pathogens, two species of which can cause opportunistic human infections.

Bacterial genetics, Bacteria, Pathogenic, Pathogenic bacteria, Genetic regulation, Genetic transcription, Transcription (Genetics), Lipoproteins, Iron, Iron (Metal), Microbiological chemistry, Opportunistic infections

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Chemotaxis in the human gastric pathogen Helicobacter pylori: different roles for cheW and the three cheV paralogues, and evidence for cheV2 phosphoryl;ation

Article Abstract:

Genomic analyses of Helicobacter pylori reveal three paralogues of the cheV gene involved in the chemotaxis function. The cheV1 encodes a bi-functional protein, with N-terminal homology to the signalling-complex linker protein CheW, which mediates chemotactic signal-transduction pathway in H. pylori.

Cellular signal transduction, Chemotaxis, Structure-activity relationships (Biochemistry), Helicobacter pylori

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