Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders
Article Abstract:
Studies have revealed that the machinery for flagellar assembly/disassembly is regulated by homologs of mitotic proteins, that cilia play essential roles in sensory transduction. Mutations in cilia/basal body proteins are responsible for cilia-related human disorders from polycystic kidney disease to a syndrome associated with obesity and diabetes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis
Article Abstract:
The repertoire of specialized proteins needed for the formation and function of cilia is defined. A comparative genomics is used to analyze the genomes of organisms with prototypical cilia, modified cilia, or no cilia and identified approximately 200 genes that are absent in the genomes of nonciliated eukaryotes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Life without centrioles: Cilia in the spotlight
Article Abstract:
Centrioles are vital cellular components that form the main architectural core of both centrosomes and basal bodies, the nucleating structures of cilia. The lack of sensory cilia has shown that acentriolar flies can develop normally but die early in adulthood.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Detection, quantitation, and phylogenetic analysis of noroviruses in Japanese oysters. Virus-contaminated oysters: a three-month monitoring of oysters imported to Switzerland
- Abstracts: Source tracking aerosols released from land-applied class B biosolids during high-wind events. Wide Geographic distribution of bacteriophages that lyse the same indigenous freshwater isolate (Sphingomonas sp. strain B18)
- Abstracts: Spatial and temporal genetic variability in French populations of the peach-potato aphid, Myzus persicae. Nuclear and chloroplast genetic structure indicate fine-scale spatial dynamics in a neotropical tree population
- Abstracts: Competition affects gene flow from oilseed rape to Brassica rapa
- Abstracts: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets