Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes
Article Abstract:
Variations in chromosome 21 gene-expression in Down syndrome were analyzed in lymphoblastoid cells derived from patients and control individuals. It is concluded that alternative transcripts belonging to the same gene are similarly regulated in Down syndrome but sense and antisense transcripts are not.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Genetic aspects, Lymphocyte transformation, Gene expression, Down syndrome
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single- nucleotide polymorphism related to phenotypes
Article Abstract:
The article describes that single nucleotide located in targets 3' untranslated region (UTR) of protein- coding genes can affect miRNA regulation.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Genetic code, Single nucleotide polymorphisms
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Subjects list: Research
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