Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
Article Abstract:
Components of an Skp1-cullin-F-box (SCF) ubiquitin ligase are discussed relative to their regulation of the centrosome duplication cycle and their localization to the centrosome. Candidate centrosomal F-box proteins have been identified. There is indication that distinct SCF complexes may direct proteolysis of factors that mediate steps in the the centrosome cycle. It has been shown that in mammalian cells the Skp1 protein and the cullin Cul1 are localized to interphase and mitotic centrosomes and to the cytoplasm and nucleus.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
Article Abstract:
A demonstration that APC/C inhibitor Emi1 tightly binds both the APC/C and its Cdh1 activator, binds to the D-box receptor site on the APC/[C.sup.Cdh1], and competes with APC/C substrates for D-box binding. Emi1 itself contains a conserved C-terminal D-box, which provides APC/C-binding affinity, and a conserved zinc-binding region (ZBR), which antagonizes APC/C E3 ligase activity independent of tight APC binding.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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