Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons
Article Abstract:
Analysis of the mechanisms responsible for the growth of ventral neurons by examining the growth of dopaminergic (DA) neurons that are present near the motoneurons in ventral midbrain shows that DA neurons grow near the floor plate, which specifies the neurons in vivo and in vitro. Association with floor plate cells is essential for the activation of DA neuronal growth. Thus, the combined function of the contact-dependent and diffusible signals from the floorplate is capable of inducing neuronal diversification in the dorsal-ventral axis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
Article Abstract:
An investigation was conducted to determine the signals that indicate the fates and initial positions of dopaminergic and serotonergic neurons which appear in the dorso-ventral and anterior-posterior axes of the neural tube. Induction sites for dopaminergic neurons are created by the intersections of Shh and FGF8. Results revealed that cell patterning in the neural plates involves multistep process for the regionalization of the tissue which is executed in multiple local organizing centers.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
Article Abstract:
The effects of netrin-1 on commisural axions of chicks are mediated by the Deleted in Colorectal Cancer (DCC) gene via cellular signal transduction pathway. The DCC gene is a netrin-1 binding protein that is expressed on the axons and growth cones of spinal commissural neurons during their migration to the floor plate. The binding protein also acts as a receptor during the guidance of commissural axons from the dorsal to the ventral midline region of the spinal cord.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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