Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.
Article Abstract:
Te mporal specification of certain visceral motor neurons and serotonergic ne ur ons was found to vary along the anterior-posterior axis of the hindbrain. Also the timing of their generation depends critically on the integrated activities of Nkx- and Hox-class homeodomain proteins. T o investigate , s equential generation of visceral motor neurons and serotonergic neurons from a common pool of neural progenitors in the ventral hindbrain was studied.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
Article Abstract:
A study shows Olig2 antagonizes the premature expression of post-mitotic motor neuron genes in pMN cells. The findings also show that the antagonistic relationship between Ngn2 and Olig2 is mediated by protein interactions that squelch activity as well as competition for shared DNA-binding sites.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Delays in neuronal differentiation in Mash1/Ascl 1 mutants
Article Abstract:
A study examines the production of cells in the neuronal of embryo of mouse and the factors that affect its development.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
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