Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: Multiple significant associations with alcohol dependence
Article Abstract:
A study aims to extend the structured association (SA) approach and to overcome its limitations by developing a novel method, which is called 'diplotype trend regression' (DTR) analysis, a method similar to haplotype trend regression. The study genotyped 16 markers within the alcohol dehydrogenase gene cluster and 4 markers within the aldehyde dehydrogenase2 gene and 38 unlinked ancestry-informative markers in a case-control sample of 801 individuals.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Accommodating linkage disequilibrium in genetic-association analyses via ridge regression
Article Abstract:
The significance of the ridge regression and related techniques in studying the linkage disequilibrium (LD) in genetic-association analyses is discussed. The techniques are extremely effective due to their ability of differentiating causative and noncausative variations in the analyses.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
User Contributions:
Comment about this article or add new information about this topic:
Genome wide linkage for opioid dependence and related traits
Article Abstract:
A genome wide linkage scan for opioid dependence (OD) and related traits is presented. An attempt is made to identify the chromosomal location of genes that increase risk of OD and related traits identified using data reduction and cluster analytic approaches.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Basin-wide analysis of the dynamics of fecal contamination and fecal source identification in Tillamook Bay, Oregon
- Abstracts: Expression profiles of bovine genes in the rectoanal junction mucosa during colonization with Escherichia coli O157:H7
- Abstracts: Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes
- Abstracts: Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase
- Abstracts: Structural basis for the autoinhibition of calcium/calmodium-dependent protein kinase I. Structural analysis of autoinhibition in the Ras activator Son of sevenless