Bcl-2 can rescue T lymphocyte dvelopment in interleukin-7 receptor-deficient mice but not in mutant rag-1(super -l-) mice

Article Abstract:

A deficiency in interleukin-7 (IL-7) receptor among mice causes them to be lymphopenic since the occurrence of defects in cell expansion becomes greater. As a result, the few mature T cells that develop in IL-7R(super -l-) animals are functionally impaired. However, the overexpression of antiapoptosis protein Bcl-2 resolves these defects by blocking positive signals resulting to the death of impaired T cells.

Research, Genetic aspects, Mice, Mice (Rodents), Interleukins, Lymphocytes

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Nicholas (Nick) R. Cozzarelli: 1938-2006

Article Abstract:

Nicholas R. Cozzarelli, professor of cell and molecular biology at the University of California, Berkeley, was a mechanistic biochemist by training. He spent his whole research career working and thinking about DNA.

United States, Executive changes & profiles, Officials and employees, Biography, Medical colleges, Medical school faculty, University of California, Medical teaching personnel, Cozzarelli, Nicholas R.

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