Downstream control of upstream open reading frames
Article Abstract:
Important new insights into upstream open reading frames (u-ORF) mediated regulatory mechanisms are provided and the findings show that in the absence of the Her-2 3UTR, the Her-2, uORF is inhibitory in all cell types tested, but the 3 UTR relieves inhibition in specific tumor cells. Future work delineating the cis-acting sequences in the 5 UTR and 3 UTR's and determining which factors are essential will help elucidate the underlying mechanism of Her-2 over expression in cancer cells.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Ehd1, a b-type response regulator in rice, confers short-day promotion of flowering and controls FT-like gene expression independently of Hd1
Article Abstract:
The rice early heading date 1 (Ehd 1) gene, that confers SD promotion of flowering in the absence of a functional allele of Hd1, encodes a Bb-type response regulator. The signaling cascade is integrated into the conserved pathway in the photoperiodic control of flowering in rice.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Long-range action of Nodal requires interaction with GDF1
Article Abstract:
A study shows that the exact function of the growth/differentiation factor 1 (GDF1) is not an effective ligand but directly interacts with Nodal, thereby increasing its specific activity.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Structural elements of the Streptomyces oriC region and their interactions with the DnaA protein. Inhibition of chromosome replication in Mycobacterium smegmatis: effect of the rpmH-dnaA promotor region
- Abstracts: Bacterial colonization of particles: growth and interactions
- Abstracts: Movement of viruses between biomes. Distribution and diversity of archael ammonia monooxygenase genes associated with corals
- Abstracts: Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of cubitus interruptus
- Abstracts: Regulating the regulator: The control of auxin transport. TIRs of joy: New receptors for auxin. Plant hormones and homeoboxes: bridging the gap?