E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells

Article Abstract:

A cellular receptor known as E-adhering is proven to mediate the entry of gram-positive bacteria into cells that are non-phagocytotic. Results of affinity chromatography show that E-cadherin is the ligand for internalin, which is known to be essential for epithelial cell entry. Morever, the results also show that the use of E-cadherin's chicken homolog in transfected fibroblasts leads to higher entry levels of Listeria monocytogenes. While the use of this homolog can also promote recombinant L. innocua, it does not promote entry of the wild-type noninvasive L. innocua.

Bacterial infections, Cell receptors, Listeria monocytogenes, Phagocytosis, Affinity chromatography

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Problems with RHAMM: a new link between surface adhesion and oncogenesis?

Article Abstract:

An exciting report by C.L. Hall et al. reported on a unique mechanism of cell transformation in which a matrix receptor linked by a GPI anchor to the external surface of the plasma membrane, called RHAMM (receptor for hyaluronic acid mediated motility), functioned as a dominant oncogene requires some comment. Experiments do not agree with major splicing-based variation in RHAMM gene products. Also, the RHAMM cDNA clone used in Hall's experiments encodes an N-terminally truncated nonnative RHAMM protein.

Proteins, Cell membranes, Plasma membranes, Oncogenes

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