From computer simulations to human disease: emerging themes in protein folding
Article Abstract:
Understanding the unique functional three-dimensional structure of protein molecules is yet to be achieved by the science community. To discuss the progress of protein folding research, a three-day meeting in Madrid, Spain was organized, which 70 scientists attended. During the meeting, it was revealed that scientists are closed to solving the puzzle of protein folding, which they hope to achieve with the invention of new techniques equipment. These include stopped flow circular dichroism, protein engineering methods and stopped flow fluorescence.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
GroEL: More than just a folding cage
Article Abstract:
The chaperonin GroEL is an important but passive player in protein folding, that provides an encapsulated environment that allows folding to proceed unimpaired by aggregation. The GroEL central cavity is redesigned and it is shown that the chaperonin cage can alter the rate of folding and for some proteins, could even alter the folding mechanism.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity
Article Abstract:
Results show that the chaperonin GroEL in combination with cochaperonin GroES mediates protein folding in Escherichia coli. The crystal structures of the bound peptide, apical domains of GroEL, and GroEL complexes are presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The somatic mutation theory of cancer: Growing problems with the paradigm? Problems of somatic mutation and cancer
- Abstracts: EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
- Abstracts: Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Post-translational modifications influence transcription factor activity: A view from the ETS superfamily
- Abstracts: TGF-beta regulation by Emilin1: New links in the etiology of hypertension. Bmp signaling: Turning a half into a whole
- Abstracts: Molecular characterization of Cryptosporidium isolates from humans and animals in Iran. Application of genotyping during an extensive outbreak of waterborne giardiasis in Bergen, Norway, during autumn and winter 2004