Functional variants in the promoter region of chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia
Article Abstract:
A significant positive association is observed between the functional variants in the promoter region of the chitinase 3-like 1 (CHI3L1) gene and the genetic risk of schizophrenia in family-based and population-based investigations. The findings identify CHI3L1 as a potential schizophrenia-susceptibility gene and suggest that the genes involved in the biological response to adverse environmental conditions are likely to play a role in the predisposition to schizophrenia.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
HLA-B maternal-fetal genotype matching increases risk of schizophrenia
Article Abstract:
A family-based candidate-gene study assesses maternal-fetal genotype matching at human leucocyte antigen-A (HLA-A), -B and -DRB1 as a risk factor of schizophrenia in offspring. The approach demonstrates the use of genetic markers to characterize the biology of prenatal risk factors of schizophrenia, and findings support the neurodevelopmental hypothesis of schizophrenia, and also suggest that the prenatal period is involved in the origin of this disease.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Schizophrenia and oxidative stress: Glutamate cysteine ligase modifier as a susceptibility gene
Article Abstract:
A strong evidence for an association between schizophrenia and the gene of the key Glutathione (GSH)-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit is presented. It is observed that GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Mitochondrial DNA variation in the European otter (Lutra lutra) and the use of spatial autocorrelation analysis in conservation
- Abstracts: A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Hematopoietic stem cell fate is established by the Notch-Runx pathway
- Abstracts: Trait components provide tools to dissect the genetic susceptibility of migraine. Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly
- Abstracts: Evidence that mutations in the X-linked DDP gene cause incompletely penetrant and variable skewed X inactivation
- Abstracts: Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause 'cone dystrophy with supernormal rod electroretinogram' in humans. part 2