The MHC reactivity of the T cell repertoire prior to positive and negative selection

Article Abstract:

Mice deficient in major histocompatibility complex (MHC) molecules I and II were analyzed to determine T cell specificities in the absence of MHC expression. Analysis of the MHC reactivity of germline T cell receptor (TCR) sequences indicated the presence of inherent MHC reactivity in TCRs due to the specific interaction of the receptors with MHC. Coreceptor signaling induced by anti-CD4 antibody promoted positive selection in a manner that was similar to MHC-mediated positive selection in vivo. Furthermore, the preselection repertoire exhibited high reactivity with MHC-expressing cells.

Physiological aspects, T cell antigen receptors, Major histocompatibility complex, T cells, Antigens

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Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)

Article Abstract:

Mutations of the XH2 gene cause the ATR-X syndrome. Mutant XH2 appears to down-regulate expression of several genes, suggesting that it is a global transcriptional regulator. XH2 belongs to the SNF2 subgroup of a helicase superfamily, and may be involved in other disorders stemming from Xq13 abnormalities.

Research, Genetic aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Mutation (Biology), Mutation, Mental retardation, Thalassemia

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