MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice

Article Abstract:

MutS homolog 4 (Msh4) must be localized to meiotic chromosomes if chromosome pairing is to take place in meiosis in mice of both sexes. MSH4 is in nuclei of spermatocytes early in prophase I. It forms definite separate loci along meiotic chromosomes in the pachytene and zygotene parts of meiosis. If the Msh4 gene is disrupted in mice sterility comes from meiotic failure.

Genetic recombination, Mammals, Germ cells, Molecular genetics

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Inactivation of exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

Article Abstract:

Research has been conducted on exonuclease 1. The role of this exonuclease in mammalian mismatch repair and the importance of exonuclease 1 for turmogenesis and meiosis have been investigated, and the results are reported.

Science & research, Causes of, Cancer, Cancer genetics, Infertility, Oncogenes, Genetic research, Exonucleases

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Meiotic pachytene arrest in MLH1-deficient mice

Article Abstract:

Cells of male mice deficient in the MLH1 gene fail to progress beyond the pachytene stage, which ultimately leads to apoptosis, suggesting that normal MLH1 function is necessary for meiotic progression. Mutant females and males are sterile. Mating behavior is normal in homozygous mutant males but the sperms fail to mature. The estrous cycles and reproductive and mating behavior in females are normal. The oocyte development in female mutants is similar to those in wild-type mice.

Gene mutations, Gene mutation, Mice as laboratory animals, House mouse

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