Unified nomenclature for the winged helix/forkhead transcription factors

Article Abstract:

Unified nomenclature has been proposed for the winged helix/forkhead transcription factors. The class of transcription factors is characterized by a 100-amino acid monomeric DNA-binding domain which folds into a variation on the helix-turn-helix pattern. It comprises three alpha helices and two characteristic large loops, or 'wings.' All Fox proteins have the 100-amino acid winged helix domain. Phylogenetic analysis was used to define 15 subclasses for all known chordate Fox proteins; they were assigned to subclasses based on the analysis. The Human and Mouse Gene Nomenclature Committees have endorsed the proposal as have 20+ scientists. Fox Nomenclature Website: http://www.biology.pomona.edu/fox.html.

Usage, Identification and classification, Terminology, Taxonomy (Biology), Phylogeny, Cladistic analysis, Biology, Binding sites (Biochemistry), Active sites (Biochemistry), DNA binding proteins

---

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

Article Abstract:

Tissue-specific deletion of Foxa2 in pancreatic beta cells has been found to result in hyperinsulinemic hypoglycemia. Mice having no Foxa2 specifically in pancreatic beta cells were generated and its contribution to beta-cell development and physiology analyzed.

France, Statistical Data Included, Newborn infants, Pancreas, Familial diseases, Hypoglycemia, Hypoglycemia in newborn infants

---

Inactivation of the winged helix transcription factor HNF3 alpha affects glucose homeostasis and islet glucagon gene expression in vivo

Article Abstract:

It appears that hepatocyte nuclear factor 3-alpha (HNF3-alpha) has a central role in the regulatory control of islet genes essential for glucose homeostasis in vivo. HNF3-alpha can bind to and transactivate the proglucagon gene promoter. Mice homozygous for a null mutation in the winged helix transcription factor, HNF3-alpha, have severe growth retardation postnatally and then die between P2 and P12.

Canada, Cellular signal transduction, Metabolic regulation, Cell differentiation

Similar abstracts:

• Abstracts: Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression
• Abstracts: Purification and characterization of the recombinant Thermus sp. strain T2 alpha-galactosidase expressed in Escherichia coli
• Abstracts: Identification of the heat-shock sigma factor RpoH and a second RpoH-like protein in Sinorhizobium meliloti. Molecular characterization of Pseudomonas putida KT2440 rpoH gene regulation
• Abstracts: Organization and regulation of meta cleavage pathway genes for toluene and o-xylene derivative degradation in Pseudomonas stutzeri OX1
• Abstracts: Cloning and characterization of the NapA acid phosphatase phosphotransferase of Morganella morganii: identification of a new family of bacterial acid-phosphatase-encoding genes

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.