Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR(alpha) and LXR(beta)
Article Abstract:
The liver X receptors (LXRs), members of the nuclear hormone receptor superfamily bound and activated by oxysterols, are discussed. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by LXR(alpha) and LXR(beta) has been studied. Findings show a unique regulatory relationship between cholesterol and fatty acid metabolism.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Role of LXRs in control of lipogenesis
Article Abstract:
The role of liver X receptors (LXRs) in the control of lipogenesis is discussed. A nonsteroidal LXR agonist and its analog have been identified and the biochemical features have been investigated. Studies of a complementary nature have yielded data that suggest that increase in plasma lipids comes though LXR-mediated induction of the sterol regulatory element-binding protein1 (SREBP-1) lipogenic process. It appears the hypertriglyceridemic effect is associated.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
Article Abstract:
When the nuclear type of sterol regulatory element-binding protein-1c (nSREBP-1c/ADD1) is overexpressed in cultured 3T3-LI preadipocytes, adipocyte differentiation occurs. Transgenic mice with overexpression of nSREBP-1c in fat tissue have been produced under regulation of the adipocyte-specific aP2 enhancer/promoter. Disordered differentiation of fat tissue, insulin resistance of significance, diabetes mellitus and fatty liver from birth, with high plasma triglyceride levels later, were seen in a syndrome. Mice of this type have many of the same things seen in congenital generalized lipodystrophy (CGL).
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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