Involvement of caspases in proteolytic cleavage of ALzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

Article Abstract:

Caspases were discovered to be responsible for directly and efficiently cleaving the amyloid-beta (A beta) precursor protein (APP) during apoptosis, which results to a rise in A beta peptide formation. It was also found that caspase-3 is the predominant caspase that induces APP cleavage. Furthermore, caspases were observed to mediate preteolypsis within the cytoplasmic tail of the APP that triggers the apoptotic death of neurons in Alzheimer's disease.

Research, Cell death, Proteolysis, Neuropeptides, Nerve proteins, Nerve tissue proteins

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Nothing in glycobiology makes sense, except in the light of evolution

Article Abstract:

The dense coating of glycans that covers all cells in nature is important for the biological processes of hosts as well as for the binding of pathogens to them. The way glycans undergo rapid evolutionary change is examined and it is suggested that pathogen selection could be an even stronger force of natural selection than previously believed.

Natural selection, Host-parasite relationships

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Inflammatory caspases: linking an intracellular innate immune system to auto inflammatory diseases

Article Abstract:

A subfamily of caspases, known as the inflammatory caspases, is associated with immune responses to microbial pathogens. The role played by such caspases, and their activation mechanisms, are reviewed.

Influence, Inflammation, Immune system

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