Last but not least: regulated poly(A) tail formation
Article Abstract:
Regulated poly(A) tail formation is discussed in this review article. Topics include polyadenylation, splicing factors as regulatory factors for 3' end processing, and a specific regulator of pre-mRNA 3' end processing. Understanding of the basic mechanism of pre-mRNA 3' end formation has advanced greatly with all but one of the essential cleavage and polyadenylation factors purified and cloned. Questions remain, however.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Securin is required for chromosomal stability in human cells
Article Abstract:
Research has been conducted on the chromosome number abnormalities, common genetic aberrations in cancer. The mechanisms which regulate the mitotic chromosome transmission in mammalian cells have been investigated and the results indicate that the human cells loose chromosomes without the hSecurin gene.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
Article Abstract:
Two pathways were found to remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Residual amounts of the cohesin SCC1 stay in association with human centromeres until the onset of anaphase when a similarly small amount of SCC1 is cleaved.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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