Linkage of the gene for an autosomal dominant form of juvenile amyotrophic lateral sclerosis to chromosome 9q34

Article Abstract:

An autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS) has been linked to a gene, ALS4, on chromosome 9q34. A gene on that chromosome is implicated as being important for motor-neuron function. Genetic mapping was carried out on an 11-generation pedigree that had the autosomal dominant, juvenile-onset motor-systems disease. The highest LOD score was found with D9S1847. Results extend the degree of heterogeneity within familial ALS syndromes.

Amyotrophic lateral sclerosis

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The gene for cherubism maps to chromosome 4p16

Article Abstract:

The gene for cherubism, an autosomal dominant disorder perhaps related to tooth development and eruption and resulting in altered facial appearance and large amounts of fibrous tissue in the jaws, has been mapped to chromosome 4p16. A genomewide search has been carried out in a 3-generation family. Three other affected families were genotyped and mapped to the locus, which is across an interval of about 22 cM.

Germany, Brazil, Bones, Abnormalities, Stomatognathic system, Jaws, Jaw, Cherubism

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