Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories
Article Abstract:
A new assay is developed to analyze the dynamics of DNA replication both spatially and temporally in individual Saccharomyces cerevisiae cells, which also helped in visualizing replication factories. This assay system has helped in finding evidence that while a replicon is in the process of DNA replication, sister replication forks remain closely associated with each other within a replication factory.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
Article Abstract:
Distinct ubiquitin-ligase complexes that define different ERAD pathways, used for the degradation if endoplasmic reticulum (ER) proteins, are identified in S. cerevisiae. It was found that all three pathways converge at the Cdc48p ATPase complex. Results lead to a unifying concept for ERAD that may also apply to mammalian cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Contribution of the endoplasmic reticulum to peroxisome formation
Article Abstract:
The trafficking route is followed for the newly made YFP-tagged PeX3 and Pex19 proteins by real-time fluorescence microscopy in Saccharomyces cerevisiae, in order to evaluate how and from where new peroxisomes are formed. The results demonstrate that peroxisomes are generated from domains in the endoplasmic reticulum.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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