Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

Article Abstract:

A study is conducted to find how loss of Lgl1 in mice results in formation of neuroepithelial rosette-like structures, similar to the neuroblastic rosettes in human primitive neuroetodermal tumors. Results reveal a vital role for mammalian Lgl1 in regulating of proliferation, differentiation, and tissue organization and demonstrate a potential causative role of disruption of cell polarity in neoplastic transformation of neuroepithelial cells.

Dysplasia

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Polarity of the mouse embryo is established at blastocyst and is not prepatterned

Article Abstract:

Polarity formation is mammalian preimplantation embryos is a subject of controversy since a long period where mechanical cues, in conjunction with the epithelial seal in the outer cell layer, lead to specification of the embryonic-abembryonic axis, thus establishing first polarity in the mouse embryo. The conclusions state that the polarity specification does not exist until the blastocyst stage.

Blastocyst

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A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation

Article Abstract:

In the skeletal myogenesis, gene expression is initiated by MyoD and includes the expression of specific Mef2 isoforms and activation of the p38 mitogen-activated protein kinase is studied. The p38 activity facilitates MyoD, Mef2 binding at a subset of late activated promoters, and the binding of Mef2d recruits Pol II.

Physiological aspects, Muscles, Gene expression, Protein kinases, Skeletal muscle

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