Marker selection for the transmission/disequilibrium test, in recently admixed populations
Article Abstract:
Results of collapsing a microsatellite into a two-allele marker have been examined for the situation in which two founding populations are assumed for the admixed population with the finding that if random mating exists, typically there is a collapsing for which the power of the transmission/disequilibrium test (TDT) is greater than that for the original microsatellite marker. A method has been developed for finding the best collapsing that has minimal dependence on a genetic disease and that uses estimates either of marker allele frequencies in the two founding populations or of marker allele frequencies in one of the found populatinos and the existing admixed population. The best collapsing is not always that with the largest difference in allele frequencies in the founding populations. An example uses 30 microsatellites in 13 populations involving Utah, French and five African populations.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Linkage disequilibrium and gene mapping: an empirical least-squares approach
Article Abstract:
The linkage-disequilibrium parameter delta can be used for fine-scale mapping of disease genes. Delta can be understood in terms of probabilities of identity-by-descent. The maximum value of delta occurs at the disease locus, where two pieces of the curve intersect. The gene location can be estimated using a semiparametric, multilocus approach to fit the nonlinear regression curve. The observed covariance structure is used to help determine the gene location.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus
Article Abstract:
Fine-scale localizing suggestions for a disease-susceptibility locus for a complex disease on the basis of deviations from Hardy-Weinberg equilibrium among affected persons are reviewed and extended. Reasons for need for care in drawing of inferences from marker Hardy-Weinberg disequilibria for disease-susceptibility loci with more than two alleles are considered with a discussion of data related to hereditary hemochromatosis.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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