Mechanism of Lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34

Article Abstract:

The process which uses the cyclin-dependent kinase inhibitor Sic1 and its ubiquitination by the cullin-RING ubiquitin ligase SCF and the ubiquitin-conjugating enzyme Cdc34 is discussed. The results showed that Sic1 ubiquitination is separated into two steps which are attachment of the first ubiquitin which is a rate limiting, followed by rapid elongation of a K48-linked ubiquitin chain.

Protein synthesis, Protein biosynthesis, Genetic research

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Structural complexity in ubiquitin recognition

Article Abstract:

A study was conducted to reveal the additional molecular mail carriers that sort and process ubiquitinated proteins and are recognized by different classes of ubiquitin binding domains (UBDs). These UBDs represent the building blocks that are often found assembled in different combinations within ubiquitin recognition and processing machines.

United States, Protein binding, Cell anatomy

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Back to the future with ubiquitin

Article Abstract:

Two papers published in 1984 by the Varshavsky laboratory on the regulatory role of the ubiquitin/ proteasome pathway are examined. The breadth of ubiquitin-mediated signaling is analyzed.

Genetic aspects, Mammal populations

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