Meiosis in Saccharomyces cerevisiae mutants lacking the centromere-binding protein CP1

Article Abstract:

CP1 protein, which is encoded by cep1, binds to the CDEI centromere DNA element in Saccharomyces cerevisiae. The role of CP1 in meiosis was determined by studying the effects of cep1 null mutations on the segregation of chromosomes, plasmids and nonessential chromosome fragments (CFs). Null mutations in cep1 resulted in missegregation of plasmids and CFs. Missegregation was also observed in an unpaired chromosome I homolog. The cep1 mutation also resulted in chromosomal nondisjunction in mitosis. These results indicate that CP1 is involved in chromatid-kinetochore adhesion.

DNA binding proteins, Meiosis, Centromeres

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MAK10, a glucose-repressible gene necessary for replication of a dsRNA virus of Saccharomyces cerevisiae, has T cell receptor alpha-subunit motifs

Article Abstract:

Saccharomyces cerevisiae's MAK10 gene encodes a protein that is glucose-repressible and contains regions similar to the alpha-subunits of T cell receptors. MAK10 is also necessary for normal growth on carbon sources that cannot be fermented. The MAK10 gene, which is required for the reproduction of the L-A dsRNA virus of Saccharomyces cerevisiae, has been isolated from bacteriophage lambda genomic DNA clones. L-A dsRNA and the mitochondrial genome are suspected to be competitors for MAK10's protein.

Genetic aspects, Plant genetics, Saccharomyces

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