Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis
Article Abstract:
Homologous chromosome synapsis in the nematode Caenorhabditis elegans is monitored to determine the role of a double-stranded DNA break-generating enzyme similar to the spo11p gene product of the yeast Saccharomyces cerevisiae. Results reveal that the enzyme requirement for meiotic recombination in C. elegans is similar to that of S. cerevisiae. However, results indicate that sister chromatid synapsis can be brought about by mechanisms other than synaptonemal complex formation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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microRNAs: tiny regulators with great potential
Article Abstract:
Regulatory RNAs of about 22 nucleotides in length, termed microRNAs, exhibit diverse sequence and expression pathways with important role in gene expression and regulation. About 90 different microRNA genes are identified so far in worms, flies, and humans. These noncoding RNA genes participate in the developmental processes and are tissue-specific.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Article Abstract:
C. elegans uses EGL-9 as a dioxygenase for the regulation of the transcriptional complex, HIF, by prolyl hydroxylation. In mammalian cells, the HIF-prolyl hydroxylases are isoforms that possess a conserved 2-histidine-1-carboxylate iron coordination motif at the site of catalysis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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