Membrane organization and tumorgenesis-The NF2 tumor suppressor, Merlin
Article Abstract:
Merlin, like the closely related Ezrin, Radixin and Moesin proteins, appears to provide regulated linkage between membrane-associated proteins and the actin cytoskeleton and is therefore poised to function in receiving and interpreting signals from the extracellular milieu. It is suggested that Merlin may coordinate the processes of growth-factor receptor signaling and cell adhesion.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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NF2 deficiency promlotes turmogenesis and metastasis by destabilizing adherens junctions
Article Abstract:
Research has been conducted on Neurofibromatosis 2 tumor suppressor genes. The authors report that the cellular consequence of Neurofibromatosis 2 deficiency in cells is caused by inability to undergo contact-dependent growth arrest and to form cadherin-containing cell:cell junctions.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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Impact of p53 loss on reversal and recurrence of conditional Wnt-induced turmorigenesis
Article Abstract:
Research has been conducted on Wnt pathway. The authors demonstrate that targeted down-regulation of the Wnt pathway leads to the disappearance of both Wnt-initiated invasive primary tumors and pulmonary metastases.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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- Abstracts: The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. AMPA receptor trafficking and the control of synaptic transmission
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