Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome
Article Abstract:
Results illustrate the three-dimensional structure of K homology domain along with a high-affinity RNA. Data suggest that a conserved hydrophobic amino acid residue in this domain is involved in the development of fragile X mental retardation syndrome.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
Article Abstract:
Research has been conducted on the fragile X syndrome caused by the RNA binding FMR protein absence. The coimmunoprecipitation of the mRNA with the FMRP ribonucleoprotein complex has been investigated and used in microarrays interrogation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex
Article Abstract:
Research has been conducted on the negative cofactor 2, the TATA box binding protein and DNA ternary complex. The X-ray structure of this complex has been investigated and the regulatory implications of the negative cofactor 2 heterodimer structure are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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