Microtubule function in morphological differentiation: growth zones and growth cones
Article Abstract:
Experiments on the functions of microtubules in the cytoskeletal structure of cells show notable results. Cells of animals which grow in culture usually have symmetric form and structure but when the growth media are altered or changed, they can cause asymmetric morphology on the shape of animal cells. Certain drugs that depolymerize microtubules curb the acquisition of differentiated form of cells. The probable reason for this is the existence of molecules that are accountable for motile specializations at the cell border and whose area relies on intact microtubules.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
RbI2p, a yeast protein that binds to beta-tubulin and participates in microtubule function in vivo
Article Abstract:
Three non-tubulin yeast genes are capable, when overexpressed, of rescuing cellus from the toxic excess beta-tubulin. RbI2p, a yeast protein that binds to beta-tubulin participates in microtubule morphogenesis. RbI2p binds to beta-tubulin in vivo. RbI2p has functional homology with murine cofactor A, a protein essential for in vitro assays of beta-tubulin folding. Another, RBL2, rescues beta-tubulin lethality as well as alpha-tubulin does.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
CLIP-170 highlights growing microtubule ends in vivo
Article Abstract:
A chimera with the green fluorescent protein (GFP) was produced to examine the dynamic characteristics of the endosome-microtubule linker protein CLIP-170 (GFP-CLIP170). GFP-CLIP170 was observed to bind in stretches along a subset of microtubule ends. Findings suggest that GFP-CLIP170 emphasizes growing microtubule ends by specifically recognizing the structure of a portion of newly polymerized tubulin.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Morphological differentiation of brown-headed cowbirds in the Okanagan Valley, British Columbia. Roost site selection of great horned owls in relation to black fly activity: an anti-parasite behavior
- Abstracts: Trans-Beringia comparisons of mitochondrial DNA differentiation in birds. Different post-Pleistocene histories of Eurasian parids
- Abstracts: Functional redundancy of genes for sulphate activation enzymes in Rhizobium sp. BR816. Phylogenetic relationships and host range of Rhizobium spp. that nodulate Phaseolus vulagaris L
- Abstracts: Denitrifying bacteria in the earthworm gastrointestinal tract and in vivo emission of nitrous oxide (N2O) by earthworms
- Abstracts: In vitro guidance of retinal ganglion cell axons by RAGs, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases