Mimicry grasps reality in translation termination
Article Abstract:
Mimicry and translation termination are discussed in this minireview article. Termination of protein synthesis takes place on the ribosomes as a response to a stop, rather than a sense codon in the decoding site. Mechanisms of stop codon recognition and translation termination by release factors (RFs) from the perspective of molecular mimicry between translation factors and tRNA. Polypeptide release factors are essential in the termination of protein synthesis on ribosomes as a response to a stop codon. Remarkably, four decades elapsed between discovery of the genetic code and figuring out basic mechanisms behind deciphering the 64 codons.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Peptidyl-tRNA regulates the GTPase activity of translation factors
Article Abstract:
Research demonstrates the mechanism involved in controlling the binding and GTPase activity of translation factors by the position of peptidyl-tRNA in the ribosome. Data indicate that hybrid sites for tRNA on the ribosomes mediate translocation of tRNAs, recycling of class 1 release factors, and recycling of ribosomes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3
Article Abstract:
Research shows that the peptide release factor RF3, involved in the translation termination, is bound to GDP, whereas RF1 or RF2 complexed with ribosome function as guanine nucleotide exchange factors. Data indicate that peptidyl-tRNA hydrolysis by RF1 or RF2 leads to GTP binding to RF3 on the ribosome.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa
- Abstracts: Structural basis for activation of ARF GTPase: Mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
- Abstracts: c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
- Abstracts: The Drosophila Brahma complex is an essential coactivator for the trithorax group protein Zeste. Functional antagonism between E2F family members
- Abstracts: MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis. MAD2B is an inhibitor of the anaphase-promoting complex