Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage

Article Abstract:

Signal transduction and transcription in the melanocyte lineage are discussed in this review article. Gene expression and how it is controlled in neural crest-derived melanocytes by interaction of specific transcription factors and signal transduction pathways are emphasized along with regulation of the expression and function of the microphthalmia-associated transcription factor, Mitf. Mouse studies and zerbrafish studies will be valuable in the study of melanocyte development. It will give novel insights into the integration of gene expression and signal transduction pathways and how they control development of a specific cell lineage.

United Kingdom, Cellular signal transduction, Genetic regulation, Genetic transcription, Transcription (Genetics), Cell differentiation, Neural crest, Melanocytes, Skin color, Color of eyes, Eye color

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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Article Abstract:

The microphthalmia-associated transcription factor, Mitf, is identified as a novel regulator of the DIAPH1 gene encoding the diaphanous-related formin Dia1 that controls actin polymerization. The results have implied that the variations in the repertoire of environmental cues that determine Mitf activity would dictate the differentiation, proliferative and invasive/migratory potential of melanoma cells through a dynamic epigenic mechanism.

Science & research, Cancer invasiveness, Actin, Cell proliferation, Structure, Chemical properties, Report

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Complete lack of NF-(kappa)B activity in IKK1 and IKK2 double-deficient mice: aditional defect in neurulation

Article Abstract:

NF-(kappa)B activity has been found to be entirely absent in IKK1 and IKK2 double-deficient mice and an additional defect in neurulation was seen. The mice lacking these critical kinases died at E12. Data suggest the kinases, induced by stress, pathogens, and cytokines, are needed for NF-(kappa)B activation in vivo and are important in protecting neurons against apoptosis during development.

United States, France, Usage, Cell death, Stress (Physiology), Neurons, Protein kinases, Cytokines, Genetically modified mice, Pathogenic microorganisms

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