Mitotic phosphorylation of histone H3 is governed by lpl1/aurora kinase and glc7/PP1 phosphatase in budding yeast and nematodes
Article Abstract:
Results demonstrate that in Saccharaomyces cerevisiae and Caenorhabditis elegans, the phosphorylation of histones plays a key role in the proper segregation of chromosomes in mitotic cell division. Data further indicate that aurora kinase and its genetically related phosphatase are involved in the phosphorylation process.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
Article Abstract:
Research has been conducted on histone H2B. The authors report that phosphorylation of this histone at serine 14 correlates with cell death in vertebrates, and that apoptosis-induced H2B kinase has been identified as caspase-cleaved mammalian sterile twenty kinase.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae
Article Abstract:
H2B is specifically phosphorylated at serine 10 (S10) in a hydrogen peroxide-induced cell death pathway in S. cerevisiae. Conservation of targeted H2B phosphorylation and the enzyme system responsible for the process point to an ancient mechanism of chromatin remodeling that likely plays an important role in governing cellular homeostasis in a wide range of organisms.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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