Molecular mechanisms in cell-mediated cytotoxicity
Article Abstract:
Cell-mediated cytotoxicity by cytotoxic T lymphocytes involved two independent mechanisms involving the initiation of apoptosis via granule exocytosis and a nonsecretory mechanisms involving the Fas ligand. Granule exocytosis was characterized by the interaction of two type of molecules that were released into the intercellular space after contact between effector and target cells. On the other hand, the nonsecretory pathway was characterized by the interaction of the CD95 ligand with the apoptosis-inducer CD95 molecule that was expressed in the natural killer cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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A Notch affair
Article Abstract:
The importance of the Notch gene among several species is highlighted in a meeting among groups studying the function and regulation of this gene in Drosophila, C. elegans and vertebrates. The meeting was held from Mar 9-11, 1998 in Madrid, Spain. Among the issues addressed during the meeting are signal transduction mechanisms, regulation of the Notch gene and the effects of gene activation on the development of the organism.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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