Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

Article Abstract:

Monocytic leukemia zinc finger protein (MOZ), a transcriptional coactivator and member of the MYST family of histone acetyltransferases, is the target of recurrent translocations in acute myeloid leukemia. It was investigated if Moz has a role in normal hematopoiesis, and it was found that Moz is essential for a basic property of hemotopoietic stem cells, the ability to reconstitute the hematopoietic system of a recipient after transplantation and is specifically required in the stem cell compartment.

United States, Genetic aspects, Histones, Leukemia, Hematopoietic agents, Nonlymphoid leukemia, Myeloid leukemia, Myelocytic leukemia

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Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment

Article Abstract:

Early B-lymphopoiesis requires the growth-factor receptors, IL-7R and Flt3, and the activity of a number of transcription factors and one factor Pax5, is required for commitment to the B-cell lineage, although the molecular mechanism by which this occurs is unknown. An important function of Pax5 is to repress Flt3 transcription in B-cell progenitors and the findings demonstrate that the repression of Flt3 by Pax5 is essential for normal B-lymphopoiesis.

B cells, Growth factor receptors

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Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene

Article Abstract:

Identification of SLAIN1, a novel stem cell gene, using human and mouse embryonic cells' transcriptional profiling is presented.

Australia, Genetic transcription, Transcription (Genetics), Stem cell research

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