Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus
Article Abstract:
Xe-Wee1 is necessary for the Mos-mediated M-phase delay in the first mitotic cell cycle of Xenopus, an organism in which a remarkable series of essentail cell-cycle transitions occurs in propagation and development. Xe-Wee1 tryosine autophosphorylation positively regulates Xe-Wee1. It is detected only in the first 30 min of the first cell cycle. The tyrosine phosphorylation of Xe-Wee1 is necessary for the Mos-mediated M-phase delay. Mos positively regulates Xe-Wee1 to generate the G2 phase in the first cell cycle and to establish a direct link between the mitogen-activated protein kinase (MAPK) signal transduction pathway and Wee1 in vertebrates.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor
Article Abstract:
Pre-mRNA splicing of IgM exons M1 and M2 is controlled by a juxtaposed splicing inhibitor/enhancer. Certain pre-mRNA introns depend for splicing on an enhancer element, typically a purine-rich one. It is thought, in general, that enhancers increase use of suboptimal splicing signals. One scenario calls for enhancers to stabilize binding of U2AF (super 65) to weak polypyrimide (Py) tracts. The model has been tested using an IgM pre-mRNA substrate containing an enhancer that has been well characterized.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans
Article Abstract:
Results show that TRA-2 interacts with the transcription factor TRA-1A directly and is mediated by MX region of TRA-2. Data from somatic mutation experiments point out that TRA-2 promotes somatic female development by inhibiting FEM-3 in Caenorhabditis elegans.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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