Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation

Article Abstract:

Research has been conducted on the apical ectodermal ridge (AER). The genetic and cellular events regulating AER formation in the mouse have been investigated.

Germany, Extremities (Anatomy), Ectoderm

---

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation

Article Abstract:

Research has been conducted on the N-myc and c-myc of cellular oncogenes family. The replacement of the endogenous c-myc coding sequences with N-myc coding sequences in mice has been examined.

Growth factors, Gene expression, Oncogenes

---

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

Article Abstract:

The inactivation of the XRCC4 gene in mice through gene-targeted mutation reveals that deficiency in XRCC4 results in several cellular and lymphocyte developmental problems. These defects are similar to those found in the presence of Ku and ligase IV deficiency, which implies that they are generated through an imperfect DNA end-joining pathway that features Ku, ligase IV and XRCC4. Unlike Ku deficiency, XRCC4 deficiency results in embryonic lethality in relation to massive apoptotic death of newly developed, postmitotic neurnoal cells across the developing nervous system.

Gene mutations, Gene mutation, Developmental neurology, Developmental cytology

Similar abstracts:

• Abstracts: Intercellular signals regulating pancreas development and function. Structure, function, and biology of SHIP proteins
• Abstracts: The C/EBP-beta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland
• Abstracts: Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
• Abstracts: FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium
• Abstracts: Nitrite reductase genes (nirK and nirS) as functional markers to investigate diversity of denitrifying bacteria in Pacific Northwest marine sediment communities

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.