Oligonucleotide microarray analysis of genomic imbalance in children with mental retardation

Article Abstract:

Whole-genome sampling analysis with Affymetrix GeneChip Human Mapping 100K arrays is used to study 100 children with idiopathic mental retardation and normal results of standard chromosomal analysis. It is found that this technology can detect at least twice as many potentially pathogenic de novo copy-number variants, as conventional cytogenetic analysis can in people with mental retardation.

Chromosome mapping, Cytogenetics, Mental retardation, DNA microarrays, Clinical report

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Rebuilding microbial genomes

Article Abstract:

A model system in which a donor genome from H. influenza was fragmented and the pieces then modified and reassembled in an Escherichia coli host cell was examined to understand the process of genetic engineering in rebuilding microbial genomes. It was found that rebuilding and booting a genome is a feasible and efficient approach to creating a synthetic microbial cell.

Analysis, Escherichia coli, Microbial genetic engineering

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The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron

Article Abstract:

A serial analysis of gene expression (SAGE) libraries were generated from two distinct populations of single, isolated sensory neuron classes, the gustatory neuron class ASE from Caenorhabditis elegans. It was shown that the ASE motif is a binding site for the C2H2 zinc finger TF CHE-1 which is essential for the correct differentiation of the ASE gustatory neuron.

Gene expression, Caenorhabditis elegans, Neurons

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