Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Article Abstract:
The mechanisms that regulate the expression of the p16 tumor suppressor during cell transformation by oncogenic ras were analyzed in primary human diploid fibroblasts (HDF) and murine embryo fibroblast (MEF) cells. Analysis of ras transformation in primary HDF and MEF cells indicated the role of oncogenic ras in promoting premature senescence or cell-cycle arrest that was promoted by p53 and p16INK4a tumor suppressors. Permanent cell-cycle arrest occurred during the G1 phase and was characterized by the activation of p53 which induces premature senescence with p16INK4a.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation
Article Abstract:
A study demonstrates that the High-Mobility Group A (HMGA) proteins, which can promote tumorigenesis, accumulate on the chromatin of senescent of fibroblasts and are essential structural components of senescent-associated heterochromatic foci (SAHFs). Results identify a component of the senescence machinery that contributes to heterochromatin formation and imply that HMGA proteins also act in tumor suppressor networks.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Article Abstract:
Research demonstrates that the stability of the senescent state occurs through the tumor suppressor Rb-directed process involving heterochromatin alterations and silencing of E2F target genes. Data indicate distinct heterochromatic structure accumulating in senescent human fibroblasts forming the senescence-associated heterochromatic foci.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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